Prefrontal hypoactivation and recovery in insomnia.
Sleep
; 31(9): 1271-6, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18788652
ABSTRACT
STUDY OBJECTIVES:
Although subjective complaints about daytime cognitive functioning are an essential symptom of chronic insomnia, abnormalities in functional brain activation have not previously been investigated. This study was designed to investigate functional brain activation differences as a possible result of chronic insomnia, and the reversibility of these differences after nonmedicated sleep therapy.DESIGN:
Insomniacs and carefully matched controls underwent functional magnetic resonance imaging (fMRI) scanning during the performance of a category and a letter fluency task. Insomniacs were randomly assigned to either a 6-week period of nonpharmacological sleep therapy or a wait list period, after which fMRI scanning was repeated using parallel tasks. Task-related brain activation and number of generated words were considered as outcome measures.SETTING:
The outpatient sleep clinic of the VU University Medical Center, Department of Clinical Neurophysiology; fMRI was performed at the Department of Radiology.PARTICIPANTS:
Twenty-one patients suffering from chronic insomnia and 12 matched controls.INTERVENTIONS:
Nonpharmacological sleep therapy for 6 weeks, consisting of cognitive behavioral therapy, body temperature and bright light interventions, sleep hygiene, and physical activity counseling. MEASUREMENT ANDRESULTS:
Compared to controls, insomnia patients showed hypoactivation of the medial and inferior prefrontal cortical areas (Brodmann Area 9, 44-45), which recovered after sleep therapy but not after a wait list period.CONCLUSIONS:
Insomnia interferes in a reversible fashion with activation of the prefrontal cortical system during daytime task performance.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pattern Recognition, Visual
/
Semantics
/
Image Processing, Computer-Assisted
/
Magnetic Resonance Imaging
/
Prefrontal Cortex
/
Sleep Initiation and Maintenance Disorders
Type of study:
Clinical_trials
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Sleep
Year:
2008
Type:
Article
Affiliation country:
Netherlands