A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells.

Shibamiya, Aya; Hersemeyer, Karin; Schmidt Wöll, Thomas; Sedding, Daniel; Daniel, Jan-Marcus; Bauer, Stefan; Koyama, Takatoshi; Preissner, Klaus T; Kanse, Sandip M

Shibamiya, Aya; Hersemeyer, Karin; Schmidt Wöll, Thomas; Sedding, Daniel; Daniel, Jan-Marcus; Bauer, Stefan; Koyama, Takatoshi; Preissner, Klaus T; Kanse, Sandip M.

Affiliation

Shibamiya A; Institute for Biochemistry, Justus-Liebig-University, Giessen, Germany.

Blood ; 113(3): 714-22, 2009 Jan 15.

Article in En | MEDLINE | ID: mdl-18971420

Subject(s)

Endothelial Cells/metabolism; Hemostasis/physiology; Thromboplastin/metabolism; Toll-Like Receptor 3/metabolism; Animals; Blood Coagulation/drug effects; Blood Coagulation/physiology; Blotting, Western; Cells, Cultured; Cytokines/biosynthesis; Endothelial Cells/drug effects; Female; Fluorescent Antibody Technique; Gene Expression/drug effects; Humans; Interferon Inducers/pharmacology; Male; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Poly I-C/pharmacology; RNA, Small Interfering; Receptors, Pattern Recognition/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Thrombomodulin/drug effects; Thrombomodulin/metabolism; Thromboplastin/drug effects; Toll-Like Receptor 3/drug effects; Toll-Like Receptor 3/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thromboplastin / Endothelial Cells / Toll-Like Receptor 3 / Hemostasis Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Blood Year: 2009 Type: Article Affiliation country: Germany

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