Deficiency of vascular endothelial growth factor-D does not affect murine adipose tissue development.
Biochem Biophys Res Commun
; 378(2): 255-8, 2009 Jan 09.
Article
in En
| MEDLINE
| ID: mdl-19022221
ABSTRACT
Vascular endothelial growth factor (VEGF)-D deficiency had no significant effect on total body weight or on subcutaneous (SC) or gonadal (GON) adipose tissue mass of mice kept on a standard fat (SFD) or a high fat diet (HFD) for 15 weeks. The composition of SC and GON adipose tissues of VEGF-D deficient mice in terms of size and density of adipocytes or blood vessels was also comparable to that of wild-type control mice. Staining of lymphatic vessels in adipose tissue sections did not reveal marked differences between both genotypes. The absence of an effect of VEGF-D deficiency could not be explained by compensatory increases of VEGF-C expression in adipose tissues of the deficient mice. Thus, our data do not support an important role of VEGF-D in (lymph) angiogenesis or in adipose tissue development.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adipose Tissue
/
Vascular Endothelial Growth Factor D
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2009
Type:
Article
Affiliation country:
Belgium