Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.

Jeimy, Samira B; Fuller, Nola; Tasneem, Subia; Segers, Kenneth; Stafford, Alan R; Weitz, Jeffrey I; Camire, Rodney M; Nicolaes, Gerry A F; Hayward, Catherine P M

Jeimy, Samira B; Fuller, Nola; Tasneem, Subia; Segers, Kenneth; Stafford, Alan R; Weitz, Jeffrey I; Camire, Rodney M; Nicolaes, Gerry A F; Hayward, Catherine P M.

Affiliation

Jeimy SB; Department of Pathology and Molecular Medicine, Health Sciences Center, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada, L8N 3Z5.

Thromb Haemost ; 100(6): 1058-67, 2008 Dec.

Article in En | MEDLINE | ID: mdl-19132231

Subject(s)

Blood Platelets/metabolism; Blood Proteins/metabolism; Factor V/metabolism; Thrombin/metabolism; Binding, Competitive; Blood Proteins/chemistry; Circular Dichroism; Factor V/chemistry; Factor Va/metabolism; Factor Xa/metabolism; Humans; Kinetics; Phosphatidylserines/blood; Protein Binding; Protein Conformation; Recombinant Proteins/metabolism; Surface Plasmon Resonance

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Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Factor V / Blood Proteins / Thrombin Limits: Humans Language: En Journal: Thromb Haemost Year: 2008 Type: Article

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