Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull, Erin R P; Lee, Youngsoo; Nakane, Hironobu; Stracker, Travis H; Zhao, Jingfeng; Russell, Helen R; Petrini, John H J; McKinnon, Peter J

Shull, Erin R P; Lee, Youngsoo; Nakane, Hironobu; Stracker, Travis H; Zhao, Jingfeng; Russell, Helen R; Petrini, John H J; McKinnon, Peter J.

Affiliation

Shull ER; Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Genes Dev ; 23(2): 171-80, 2009 Jan 15.

Article in En | MEDLINE | ID: mdl-19171781

Subject(s)

Apoptosis; Ataxia Telangiectasia/physiopathology; DNA Damage/physiology; Neurons/physiology; Nijmegen Breakage Syndrome/physiopathology; Signal Transduction/genetics; Animals; Apoptosis/radiation effects; Ataxia Telangiectasia/genetics; Ataxia Telangiectasia Mutated Proteins; Brain/pathology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; DNA Damage/genetics; DNA Ligase ATP; DNA Ligases/metabolism; DNA Repair Enzymes/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Activation/physiology; Female; MRE11 Homologue Protein; Male; Mice; Mice, Transgenic; Microcephaly/pathology; Mutation; Neurons/cytology; Neurons/radiation effects; Nijmegen Breakage Syndrome/genetics; Nuclear Proteins/genetics; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Radiation, Ionizing; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Ataxia Telangiectasia / Signal Transduction / Apoptosis / Nijmegen Breakage Syndrome / Neurons Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2009 Type: Article Affiliation country: United States

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