Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice.

Fogelgren, Ben; Yang, Shiming; Sharp, Ian C; Huckstep, Odaro J; Ma, Wenbin; Somponpun, S J; Carlson, Edward C; Uyehara, Catherine F T; Lozanoff, Scott

Fogelgren, Ben; Yang, Shiming; Sharp, Ian C; Huckstep, Odaro J; Ma, Wenbin; Somponpun, S J; Carlson, Edward C; Uyehara, Catherine F T; Lozanoff, Scott.

Affiliation

Fogelgren B; Deptartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.

Am J Physiol Renal Physiol ; 296(5): F1166-78, 2009 May.

Article in En | MEDLINE | ID: mdl-19193724

Subject(s)

Homeodomain Proteins/genetics; Hypertension, Renal/physiopathology; Kidney Failure, Chronic/physiopathology; Nephrons/abnormalities; Nephrons/physiology; Transcription Factors/genetics; Animals; Down-Regulation/physiology; Endothelin-1/metabolism; Gene Expression Regulation, Developmental/physiology; Hypertension, Renal/genetics; Hypertension, Renal/pathology; Kidney Failure, Chronic/genetics; Kidney Failure, Chronic/pathology; Kidney Glomerulus/abnormalities; Kidney Glomerulus/physiology; Kidney Glomerulus/ultrastructure; Kidney Tubules/abnormalities; Kidney Tubules/physiology; Kidney Tubules/ultrastructure; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Microscopy, Electron; Nephrons/ultrastructure; Receptors, Endothelin/metabolism; Sodium-Potassium-Exchanging ATPase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Homeodomain Proteins / Hypertension, Renal / Kidney Failure, Chronic / Nephrons Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2009 Type: Article Affiliation country: United States

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