Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters.

Mortishire-Smith, Russell J; Castro-Perez, Jose M; Yu, Kate; Shockcor, John P; Goshawk, Jeff; Hartshorn, Mike J; Hill, Alastair

Mortishire-Smith, Russell J; Castro-Perez, Jose M; Yu, Kate; Shockcor, John P; Goshawk, Jeff; Hartshorn, Mike J; Hill, Alastair.

Affiliation

Mortishire-Smith RJ; Johnson & Johnson PR&D, Turnhoutseweg 30, B-2340 Beerse, Belgium. rmortish@its.jnj.com

Rapid Commun Mass Spectrom ; 23(7): 939-48, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19241416

Subject(s)

Prescription Drugs/pharmacokinetics; Spectrometry, Mass, Electrospray Ionization/methods; Animals; Chromatography, High Pressure Liquid; Dealkylation; Inactivation, Metabolic; Metabolomics; Microsomes, Liver/metabolism; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spectrometry, Mass, Electrospray Ionization / Prescription Drugs Type of study: Evaluation_studies Limits: Animals Language: En Journal: Rapid Commun Mass Spectrom Year: 2009 Type: Article Affiliation country: Belgium

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