The effect of tiotropium therapy on markers of elastin degradation in COPD.
Respir Res
; 10: 12, 2009 Feb 25.
Article
in En
| MEDLINE
| ID: mdl-19243601
ABSTRACT
BACKGROUND:
Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity. This study was undertaken to determine whether continuous therapy with the long-acting bronchodilator Tiotropium bromide (TTP) could result in reductions in D/I as measured by mass spectrometry in plasma, urine and sputum.METHODS:
Twelve not currently smoking patients with chronic obstructive pulmonary disease (COPD), never on TTP, were selected for study. Levels of D/I, along with measurements of FVC, FEV1 and FEV1/FVC. were determined before starting TTP daily, and then one and two months after.RESULTS:
D/I decreased in plasma (10 of 12 patients), in sputum all (12 of 12), and in the percentage of free D/I in urine (10 of 12). Most patients showed slight increases in FVC and FEV1 percent predicted over two months.CONCLUSION:
The results are consistent with an effect of prolonged bronchodilitation by anti-cholinergic blockade to also result in reduced lung elastin degradation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scopolamine Derivatives
/
Bronchodilator Agents
/
Elastin
/
Pulmonary Disease, Chronic Obstructive
Limits:
Humans
Language:
En
Journal:
Respir Res
Year:
2009
Type:
Article
Affiliation country:
United States