Two-stage portal vein ligation facilitates liver regeneration in rats.
Eur Surg Res
; 42(3): 181-8, 2009.
Article
in En
| MEDLINE
| ID: mdl-19246925
ABSTRACT
BACKGROUND/AIMS:
Recent reports have demonstrated that some patients are unable to undergo scheduled liver resection after preoperative portal vein embolization due to insufficient hypertrophy of the future remnant liver. The present study examined whether two-stage portal vein ligation (PVL) increases hypertrophy of the future remnant liver compared to conventional PVL in rats.METHODS:
Rats were divided into 3 groups group A, ligation of left primary branch; group B, ligation of right and left primary branches; group C, ligation of the left primary branch, followed by 2-stage PVL 7 days postoperatively. To evaluate liver regeneration, the proliferating cell nuclear antigen labeling index (LI), mitotic index (MI) in the caudate lobe and weight ratio of caudate lobe to body weight were measured.RESULTS:
The weight ratio of caudate lobe to body weight was significantly higher in group C than in groups A or B 14 days postoperatively. In groups A and B, LI and MI in the caudate lobe peaked 2 days postoperatively, then decreased to preoperative levels by 7-8 days postoperatively, but remained significantly elevated until 10-14 days postoperatively in group C.CONCLUSION:
Two-stage PVL increases hypertrophy of the future remnant liver compared to conventional PVL in rats.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Portal Vein
/
Liver Regeneration
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Eur Surg Res
Year:
2009
Type:
Article
Affiliation country:
Japan