Evaluation of a low dose, after a standard therapeutic dose, of agalsidase beta during enzyme replacement therapy in patients with Fabry disease.

Lubanda, Jean-Claude; Anijalg, Ene; Bzdúch, Vladimír; Thurberg, Beth L; Bénichou, Bernard; Tylki-Szymanska, Anna

Lubanda, Jean-Claude; Anijalg, Ene; Bzdúch, Vladimír; Thurberg, Beth L; Bénichou, Bernard; Tylki-Szymanska, Anna.

Affiliation

Lubanda JC; Clinical Department of Cardiology and Angiology, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic. lubanda@mail.cz

Genet Med ; 11(4): 256-64, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19265719

Subject(s)

Fabry Disease/drug therapy; Isoenzymes/therapeutic use; alpha-Galactosidase/therapeutic use; Adult; Biopsy; Chills/chemically induced; Diarrhea/chemically induced; Dose-Response Relationship, Drug; Endothelial Cells/metabolism; Fabry Disease/pathology; Fever/chemically induced; Follow-Up Studies; Humans; Infusions, Intravenous; Isoenzymes/administration & dosage; Isoenzymes/adverse effects; Kidney/metabolism; Kidney/pathology; Kidney/physiopathology; Kidney Function Tests; Male; Middle Aged; Skin/metabolism; Skin/pathology; Treatment Outcome; Trihexosylceramides/blood; Trihexosylceramides/metabolism; Trihexosylceramides/urine; Young Adult; alpha-Galactosidase/administration & dosage; alpha-Galactosidase/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fabry Disease / Alpha-Galactosidase / Isoenzymes Type of study: Clinical_trials / Observational_studies / Prognostic_studies Limits: Adult / Humans / Male / Middle aged Language: En Journal: Genet Med Journal subject: GENETICA MEDICA Year: 2009 Type: Article Affiliation country: Czech Republic

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