Penetration of moxifloxacin into rat mandibular bone and soft tissue.
Acta Odontol Scand
; 67(3): 182-6, 2009.
Article
in En
| MEDLINE
| ID: mdl-19306136
ABSTRACT
OBJECTIVE:
Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL ANDMETHODS:
Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis.RESULTS:
The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissueplasma were M. masseterplasma = 2.64 and mandiblesplasma = 1.13.CONCLUSIONS:
Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Periodontal Diseases
/
Quinolines
/
Aza Compounds
/
Tooth Diseases
/
Alveolar Process
/
Masseter Muscle
/
Anti-Infective Agents
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Acta Odontol Scand
Year:
2009
Type:
Article
Affiliation country:
Germany