Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake.

Monazzam, Azita; Razifar, Pasha; Ide, Susan; Rugaard Jensen, Michael; Josephsson, Raymond; Blomqvist, Carl; Langström, Bengt; Bergström, Mats

Monazzam, Azita; Razifar, Pasha; Ide, Susan; Rugaard Jensen, Michael; Josephsson, Raymond; Blomqvist, Carl; Langström, Bengt; Bergström, Mats.

Affiliation

Monazzam A; Institute of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. azita.monazzam@ge.com

Nucl Med Biol ; 36(3): 335-42, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19324279

Subject(s)

HSP90 Heat-Shock Proteins/antagonists & inhibitors; Isoxazoles/pharmacology; Neoplasms/pathology; Radioactive Tracers; Resorcinols/pharmacology; Spheroids, Cellular/metabolism; Spheroids, Cellular/pathology; Animals; Biological Transport/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Humans; Positron-Emission Tomography; Spheroids, Cellular/drug effects; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radioactive Tracers / Resorcinols / HSP90 Heat-Shock Proteins / Spheroids, Cellular / Isoxazoles / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nucl Med Biol Journal subject: BIOLOGIA / MEDICINA NUCLEAR Year: 2009 Type: Article Affiliation country: Sweden

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