Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells.
Nat Immunol
; 10(5): 488-95, 2009 May.
Article
in En
| MEDLINE
| ID: mdl-19349986
ABSTRACT
Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103(+) dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103(+) subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8(+) T cells, although all subsets presented these antigens to CD4(+) T cells. This showed that CD103(+) DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103(+) DCs efficiently cross-presented skin-derived self antigens. This indicates CD103(+) DCs are the main migratory subtype able to cross-present viral and self antigens, which identifies another level of specialization for skin DCs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Autoantigens
/
Dendritic Cells
/
Lymphocyte Activation
/
Cross-Priming
/
Antigens, Viral
Limits:
Animals
Language:
En
Journal:
Nat Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2009
Type:
Article
Affiliation country:
Australia