A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Yu, Ying; Keller, Steve H; Remillard, Carmelle V; Safrina, Olga; Nicholson, Ann; Zhang, Shenyuan L; Jiang, Weihua; Vangala, Nivruthi; Landsberg, Judd W; Wang, Jian-Ying; Thistlethwaite, Patricia A; Channick, Richard N; Robbins, Ivan M; Loyd, James E; Ghofrani, Hossein A; Grimminger, Friedrich; Schermuly, Ralph T; Cahalan, Michael D; Rubin, Lewis J; Yuan, Jason X-J

Yu, Ying; Keller, Steve H; Remillard, Carmelle V; Safrina, Olga; Nicholson, Ann; Zhang, Shenyuan L; Jiang, Weihua; Vangala, Nivruthi; Landsberg, Judd W; Wang, Jian-Ying; Thistlethwaite, Patricia A; Channick, Richard N; Robbins, Ivan M; Loyd, James E; Ghofrani, Hossein A; Grimminger, Friedrich; Schermuly, Ralph T; Cahalan, Michael D; Rubin, Lewis J; Yuan, Jason X-J.

Affiliation

Yu Y; Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0725, USA. Ying.Yu@AlconLabs.com

Circulation ; 119(17): 2313-22, 2009 May 05.

Article in En | MEDLINE | ID: mdl-19380626

Subject(s)

Hypertension/etiology; NF-kappa B/genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Pulmonary Artery/physiopathology; TRPC Cation Channels/genetics; Binding Sites/genetics; Case-Control Studies; Cell Proliferation; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension/genetics; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B/metabolism; TRPC6 Cation Channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Artery / NF-kappa B / Promoter Regions, Genetic / Polymorphism, Single Nucleotide / TRPC Cation Channels / Hypertension Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Circulation Year: 2009 Type: Article Affiliation country: United States

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