Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.

Chan, Wing-Sai; Durairajan, Siva Sundara Kumar; Lu, Jia-Hong; Wang, Yan; Xie, Li-Xia; Kum, Wan-Fung; Koo, Irene; Yung, Ken Kin Lam; Li, Min

Chan, Wing-Sai; Durairajan, Siva Sundara Kumar; Lu, Jia-Hong; Wang, Yan; Xie, Li-Xia; Kum, Wan-Fung; Koo, Irene; Yung, Ken Kin Lam; Li, Min.

Affiliation

Chan WS; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Neurochem Int ; 55(6): 414-22, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19409437

Subject(s)

Dopamine/biosynthesis; Neurons/drug effects; Neuroprotective Agents/pharmacology; Parkinson Disease/drug therapy; Saponins/pharmacology; Substantia Nigra/drug effects; Triterpenes/pharmacology; Animals; Animals, Newborn; Cell Death/drug effects; Cell Death/physiology; Cell Differentiation/drug effects; Cell Differentiation/physiology; Cells, Cultured; Dose-Response Relationship, Drug; Nerve Degeneration/chemically induced; Nerve Degeneration/drug therapy; Nerve Degeneration/physiopathology; Neurites/drug effects; Neurites/metabolism; Neurites/ultrastructure; Neurons/metabolism; Nitric Oxide Synthase Type I/drug effects; Nitric Oxide Synthase Type I/metabolism; Oxidopamine/antagonists & inhibitors; Oxidopamine/toxicity; Parkinson Disease/metabolism; Parkinson Disease/physiopathology; Rats; Rats, Sprague-Dawley; Saponins/therapeutic use; Substantia Nigra/cytology; Substantia Nigra/metabolism; Sympatholytics/antagonists & inhibitors; Sympatholytics/toxicity; Triterpenes/therapeutic use; Tyrosine 3-Monooxygenase/drug effects; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Saponins / Triterpenes / Substantia Nigra / Dopamine / Neuroprotective Agents / Neurons Language: En Journal: Neurochem Int Year: 2009 Type: Article Affiliation country: Hong Kong

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