Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.

Borojerdi, Jennifer P; Ming, Jessica; Cooch, Catherine; Ward, Yvona; Semino-Mora, Cristina; Yu, Mia; Braun, Hannan M; Taylor, Barbara J; Poirier, Miriam C; Olivero, Ofelia A

Borojerdi, Jennifer P; Ming, Jessica; Cooch, Catherine; Ward, Yvona; Semino-Mora, Cristina; Yu, Mia; Braun, Hannan M; Taylor, Barbara J; Poirier, Miriam C; Olivero, Ofelia A.

Affiliation

Borojerdi JP; Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD 20892, USA.

Mutat Res ; 665(1-2): 67-74, 2009 Jun 01.

Article in En | MEDLINE | ID: mdl-19427513

Subject(s)

Aneugens/toxicity; Aneuploidy; Centrosome/drug effects; Zidovudine/toxicity; Aneugens/pharmacokinetics; Animals; Aurora Kinases; Breast/cytology; Breast/drug effects; Breast/metabolism; CHO Cells; Cell Cycle/drug effects; Cell Line; Centrosome/metabolism; Centrosome/ultrastructure; Cricetinae; Cricetulus; DNA Adducts/metabolism; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Epithelial Cells/ultrastructure; Humans; Micronuclei, Chromosome-Defective/chemically induced; Microscopy, Electron, Transmission; Protein Serine-Threonine Kinases/metabolism; Tubulin/metabolism; Zidovudine/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zidovudine / Centrosome / Aneugens / Aneuploidy Limits: Animals / Humans Language: En Journal: Mutat Res Year: 2009 Type: Article Affiliation country: United States

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