Modeling ATM mutant proteins from missense changes confirms retained kinase activity.

Barone, Giancarlo; Groom, Alix; Reiman, Anne; Srinivasan, Venkataramanan; Byrd, Philip J; Taylor, A Malcolm R

Barone, Giancarlo; Groom, Alix; Reiman, Anne; Srinivasan, Venkataramanan; Byrd, Philip J; Taylor, A Malcolm R.

Affiliation

Barone G; Cancer Research-UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, United Kingdom.

Hum Mutat ; 30(8): 1222-30, 2009 Aug.

Article in En | MEDLINE | ID: mdl-19431188

Subject(s)

Cell Cycle Proteins/genetics; DNA-Binding Proteins/genetics; Mutation, Missense; Protein Serine-Threonine Kinases/genetics; Tumor Suppressor Proteins/genetics; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins/metabolism; Cell Division; DNA Damage; DNA Repair; DNA-Binding Proteins/metabolism; Enzyme Activation; G2 Phase; Humans; Infrared Rays; Protein Serine-Threonine Kinases/metabolism; Tumor Suppressor Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Cell Cycle Proteins / Mutation, Missense / Tumor Suppressor Proteins / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Hum Mutat Journal subject: GENETICA MEDICA Year: 2009 Type: Article Affiliation country: United kingdom

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