The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

Ferreira, Viviana P; Herbert, Andrew P; Cortés, Claudio; McKee, Kristi A; Blaum, Bärbel S; Esswein, Stefan T; Uhrín, Dusan; Barlow, Paul N; Pangburn, Michael K; Kavanagh, David

Ferreira, Viviana P; Herbert, Andrew P; Cortés, Claudio; McKee, Kristi A; Blaum, Bärbel S; Esswein, Stefan T; Uhrín, Dusan; Barlow, Paul N; Pangburn, Michael K; Kavanagh, David.

Affiliation

Ferreira VP; Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA.

J Immunol ; 182(11): 7009-18, 2009 Jun 01.

Article in En | MEDLINE | ID: mdl-19454698

Subject(s)

Complement C3b/metabolism; Complement Factor H/metabolism; Erythrocytes/immunology; Hemolytic-Uremic Syndrome/genetics; Heparin/metabolism; Mutation; Animals; Cells, Cultured; Complement Factor H/genetics; Erythrocytes/pathology; Genetic Predisposition to Disease; Hemolytic-Uremic Syndrome/immunology; Hemolytic-Uremic Syndrome/pathology; Humans; Polyelectrolytes; Polymers/metabolism; Protein Binding/genetics; Sheep

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C3b / Heparin / Complement Factor H / Erythrocytes / Hemolytic-Uremic Syndrome / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2009 Type: Article Affiliation country: United States

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