Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.

Li, Tiangang; Ma, Huiyan; Park, Young Joo; Lee, Yoon-Kwang; Strom, Stephen; Moore, David D; Chiang, John Y L

Li, Tiangang; Ma, Huiyan; Park, Young Joo; Lee, Yoon-Kwang; Strom, Stephen; Moore, David D; Chiang, John Y L.

Affiliation

Li T; Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA.

Biochim Biophys Acta ; 1791(10): 991-6, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19463968

Subject(s)

Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors; Dietary Fats/administration & dosage; Dietary Fats/pharmacology; Feeding Behavior/drug effects; Forkhead Transcription Factors/metabolism; Hepatocytes/enzymology; Adenoviridae/genetics; Animals; Bile Acids and Salts/biosynthesis; Cell Line, Tumor; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cholesterol 7-alpha-Hydroxylase/genetics; Cholesterol 7-alpha-Hydroxylase/metabolism; Down-Regulation/drug effects; Forkhead Box Protein O1; Forkhead Transcription Factors/genetics; Gene Expression Regulation, Enzymologic/drug effects; Gene Knockdown Techniques; Gene Transfer Techniques; Hepatocytes/drug effects; Humans; Insulin/metabolism; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; RNA Interference/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dietary Fats / Cholesterol 7-alpha-Hydroxylase / Hepatocytes / Forkhead Transcription Factors / Feeding Behavior Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biochim Biophys Acta Year: 2009 Type: Article Affiliation country: United States

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