Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.

Cherney, Robert J; Mo, Ruowei; Meyer, Dayton T; Voss, Matthew E; Lo, Yvonne C; Yang, Gengjie; Miller, Persymphonie B; Scherle, Peggy A; Tebben, Andrew J; Carter, Percy H; Decicco, Carl P

Cherney, Robert J; Mo, Ruowei; Meyer, Dayton T; Voss, Matthew E; Lo, Yvonne C; Yang, Gengjie; Miller, Persymphonie B; Scherle, Peggy A; Tebben, Andrew J; Carter, Percy H; Decicco, Carl P.

Affiliation

Cherney RJ; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States. robert.cherney@bms.com

Bioorg Med Chem Lett ; 19(13): 3418-22, 2009 Jul 01.

Article in En | MEDLINE | ID: mdl-19481449

Subject(s)

Cyclohexanes/chemical synthesis; Receptors, CCR2/antagonists & inhibitors; Sulfones/chemistry; Cyclohexanes/chemistry; Cyclohexanes/pharmacology; Molecular Conformation; Receptors, CCR2/metabolism; Sulfones/chemical synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Cyclohexanes / Receptors, CCR2 Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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