Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

Tedesco, Rosanna; Chai, Deping; Darcy, Michael G; Dhanak, Dashyant; Fitch, Duke M; Gates, Adam; Johnston, Victor K; Keenan, Richard M; Lin-Goerke, Juili; Sarisky, Robert T; Shaw, Antony N; Valko, Klara L; Wiggall, Kenneth J; Zimmerman, Michael N; Duffy, Kevin J

Tedesco, Rosanna; Chai, Deping; Darcy, Michael G; Dhanak, Dashyant; Fitch, Duke M; Gates, Adam; Johnston, Victor K; Keenan, Richard M; Lin-Goerke, Juili; Sarisky, Robert T; Shaw, Antony N; Valko, Klara L; Wiggall, Kenneth J; Zimmerman, Michael N; Duffy, Kevin J.

Affiliation

Tedesco R; Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, Collegeville, PA 19426, USA. Rosanna_2_Tedesco@gsk.com

Bioorg Med Chem Lett ; 19(15): 4354-8, 2009 Aug 01.

Article in En | MEDLINE | ID: mdl-19505821

Subject(s)

Chemistry, Pharmaceutical/methods; Quinolones/chemical synthesis; Viral Nonstructural Proteins/antagonists & inhibitors; Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Drug Design; Genotype; Hepacivirus/metabolism; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Protein Binding; Quinolones/pharmacology; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemistry, Pharmaceutical / Viral Nonstructural Proteins / Quinolones Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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