Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.

Abaut, A Y; Chevanne, F; Le Corre, P

Abaut, A Y; Chevanne, F; Le Corre, P.

Affiliation

Abaut AY; Unité UPRES EA 3892, Laboratoire de Pharmacie Galénique, Biopharmacie et Pharmacie Clinique Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 2 avenue du Pr Léon Bernard 35043 Rennes cedex, France.

Int J Pharm ; 378(1-2): 80-5, 2009 Aug 13.

Article in En | MEDLINE | ID: mdl-19508886

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Amitriptyline/pharmacokinetics; Multidrug Resistance-Associated Proteins/metabolism; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/genetics; Animals; Antidepressive Agents, Tricyclic/pharmacokinetics; Bile/metabolism; Brain/metabolism; Cytochrome P-450 CYP2D6/metabolism; Female; Injections, Intraperitoneal; Liver/metabolism; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Novobiocin/pharmacology; Probenecid/pharmacology; Quinidine/pharmacology; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP-Binding Cassette Transporters / Multidrug Resistance-Associated Proteins / Amitriptyline Limits: Animals Language: En Journal: Int J Pharm Year: 2009 Type: Article Affiliation country: France

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