Recent advances in synthesis of PAR ligands as therapeutic strategy for inflammatory diseases.

Severino, B; Santagada, V; Perissutti, E; Fiorino, F; Frecentese, F; De Angelis, F; Esposito, A; Caliendo, G

Severino, B; Santagada, V; Perissutti, E; Fiorino, F; Frecentese, F; De Angelis, F; Esposito, A; Caliendo, G.

Affiliation

Severino B; Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, via D. Montesano 49, -80131 Naples, Italy.

Mini Rev Med Chem ; 9(6): 653-63, 2009 Jun.

Article in En | MEDLINE | ID: mdl-19519491

ABSTRACT

ABSTRACT

Several studies have been published on discovering involvement of PARs receptors in a number of disease states, including cancer and inflammation of the cardiovascular, respiratory, musculoskeletal, gastrointestinal and nervous systems. This mini-review will focus on recent advances in the synthesis of PAR ligands highlighting their therapeutic potential in the treatment of various inflammatory diseases.

Subject(s)

Inflammation/drug therapy; Inflammation/metabolism; Organic Chemicals/chemical synthesis; Organic Chemicals/pharmacology; Receptors, Proteinase-Activated/agonists; Receptors, Proteinase-Activated/antagonists & inhibitors; Animals; Biomimetic Materials/chemical synthesis; Biomimetic Materials/chemistry; Biomimetic Materials/pharmacology; Biomimetic Materials/therapeutic use; Heterocyclic Compounds/chemical synthesis; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Heterocyclic Compounds/therapeutic use; Humans; Ligands; Organic Chemicals/chemistry; Organic Chemicals/therapeutic use; Receptors, Proteinase-Activated/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Organic Chemicals / Receptors, Proteinase-Activated / Inflammation Limits: Animals / Humans Language: En Journal: Mini Rev Med Chem Journal subject: QUIMICA Year: 2009 Type: Article Affiliation country: Italy

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