Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density.
Magn Reson Med
; 62(3): 583-90, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19526491
ABSTRACT
The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy ((1)H-MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel (1)H-MRS studies have often included measurements of water proton T(1), T(2), and density based on additional (1)H-MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for (1)H-MRS imaging ((1)H-MRSI). In this report we demonstrate a method for using in situ measurements of water T(1), T(2), and density to calculate metabolite concentrations from (1)H-MRSI data. The relaxation and density data are coregistered with the (1)H-MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject-by-subject and voxel-by-voxel basis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Water
/
Algorithms
/
Brain Chemistry
/
Water
/
Magnetic Resonance Spectroscopy
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Magn Reson Med
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2009
Type:
Article
Affiliation country:
United States