Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4.

Frank, Daniel J; Denisov, Ilia G; Sligar, Stephen G

Frank, Daniel J; Denisov, Ilia G; Sligar, Stephen G.

Affiliation

Frank DJ; School of Molecular and Cellular Biology, University of Illinois, Urbana, IL 61801, USA.

Arch Biochem Biophys ; 488(2): 146-52, 2009 Aug 15.

Article in En | MEDLINE | ID: mdl-19560436

Subject(s)

Cytochrome P-450 CYP3A/metabolism; Benzoflavones/metabolism; Binding Sites; Cytochrome P-450 CYP3A/isolation & purification; Electron Spin Resonance Spectroscopy; Escherichia coli/genetics; Heme/metabolism; Humans; Hydrophobic and Hydrophilic Interactions; Protein Binding; Solubility; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Testosterone/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Arch Biochem Biophys Year: 2009 Type: Article Affiliation country: United States

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