Building the world's best hearing aid; regulation of cell fate in the cochlea.
Curr Opin Genet Dev
; 19(4): 368-73, 2009 Aug.
Article
in En
| MEDLINE
| ID: mdl-19604683
In mammals, auditory perception is initially mediated through sensory cells located in a rigorously patterned mosaic of unique cell types located within the coiled cochlea. Identification of the factors that direct multipotent progenitor cells to develop as each of these specialized cell types has the potential to enhance our understanding of the development of the auditory system and to identify potential targets for regenerative therapies. Recent results have identified specific signaling molecules and pathways, including Notch, Hedgehog, Sox2 and Fgfs, that guide progenitor cells to develop first as a sensory precursor, referred to as a prosensory cell, and subsequently as one of the specialized cell types within the sensory mosaic.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cochlea
/
Gene Expression Regulation, Developmental
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2009
Type:
Article
Affiliation country:
United States