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(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
Lehmann, Anders; Antonsson, Madeleine; Holmberg, Ann Aurell; Blackshaw, L Ashley; Brändén, Lena; Bräuner-Osborne, Hans; Christiansen, Bolette; Dent, John; Elebring, Thomas; Jacobson, Britt-Marie; Jensen, Jörgen; Mattsson, Jan P; Nilsson, Karolina; Oja, Simo S; Page, Amanda J; Saransaari, Pirjo; von Unge, Sverker.
Affiliation
  • Lehmann A; AstraZeneca R&D, Mölndal, Sweden. anders.lehmann@astrazeneca.com
J Pharmacol Exp Ther ; 331(2): 504-12, 2009 Nov.
Article in En | MEDLINE | ID: mdl-19648470
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peripheral Nerves / Phosphinic Acids / Propylamines / GABA Agonists / Esophageal Sphincter, Lower / GABA-B Receptor Agonists Limits: Animals / Female / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2009 Type: Article Affiliation country: Sweden
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peripheral Nerves / Phosphinic Acids / Propylamines / GABA Agonists / Esophageal Sphincter, Lower / GABA-B Receptor Agonists Limits: Animals / Female / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2009 Type: Article Affiliation country: Sweden