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Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery.
Burgos, Juan M; Altcheh, Jaime; Petrucelli, Noemi; Bisio, Margarita; Levin, Mariano J; Freilij, Hector; Schijman, Alejandro G.
Affiliation
  • Burgos JM; Laboratorio de Biología Molecular de la Enfermedad de Chagas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires C1428ADL, Argentina.
Diagn Microbiol Infect Dis ; 65(1): 58-61, 2009 Sep.
Article in En | MEDLINE | ID: mdl-19679236
ABSTRACT
Congenital transmission of Trypanosoma cruzi was diagnosed in 2 triplets born to a triamniotic bichorionic delivery. Only the sisters sharing the placenta became infected, as diagnosed by microhematocrit and/or polymerase chain reaction of 3 parasite targets. The neonates' parasitologic response to benznidazole was monitored. Molecular strategies allowed genotyping lineage IId and identical minicircle signatures in both triplets, showing they harbored the same maternal parasite populations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma cruzi / Chagas Disease / Pregnancy Complications, Parasitic Type of study: Diagnostic_studies Limits: Adolescent / Animals / Female / Humans / Newborn / Pregnancy Language: En Journal: Diagn Microbiol Infect Dis Year: 2009 Type: Article Affiliation country: Argentina
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma cruzi / Chagas Disease / Pregnancy Complications, Parasitic Type of study: Diagnostic_studies Limits: Adolescent / Animals / Female / Humans / Newborn / Pregnancy Language: En Journal: Diagn Microbiol Infect Dis Year: 2009 Type: Article Affiliation country: Argentina