Assessment of chromosome 22 anomalies in neurinomas by combined karyotype and RFLP analyses.
Cancer Genet Cytogenet
; 45(1): 55-62, 1990 Mar.
Article
in En
| MEDLINE
| ID: mdl-1967977
ABSTRACT
We report the cytogenetic study of 28 neurinomas; sixteen of them were also analysed using 11 polymorphic DNA markers for the loss of alleles of chromosome 22. Partial or total loss of chromosome 22 was found in nine cases. The results of the two approaches appear homogeneous, however, three tumors that yielded only cells with normal karyotypes demonstrated loss of constitutional heterozygosities. One of the tumors, which displayed an isodicentric or isopseudodicentric 22, was obtained in a patient with von Recklinghausen neurofibromatosis. It appears that loss of chromosome 22 is a characteristic of neurinomas whatever their context of occurrence.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 22
/
Polymorphism, Restriction Fragment Length
/
Chromosome Aberrations
/
Neurilemmoma
Limits:
Humans
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
1990
Type:
Article
Affiliation country:
France