A review of the applications of tissue microarray technology in understanding the molecular features of endometrial carcinoma.
Anal Quant Cytol Histol
; 31(4): 217-26, 2009 Aug.
Article
in En
| MEDLINE
| ID: mdl-19736869
ABSTRACT
OBJECTIVE:
To review the literature regarding the use of tissue microarray (TMA) technology in understanding the biology, diagnosis and prognosis of endometrial carcinoma (EC). STUDYDESIGN:
This review of TMA technology in EC was based on a large number of published articles. We focused on the use of TMA technology as a tool to gain insight in endometrial carcinogenesis and to validate data obtained from DNA microarrays, proteomics and cellular models.RESULTS:
We summarized the technical aspects of the 37 articles that were reviewed. The number of EC cases in each series varied from 32-485 (median, 128). The number of cores ranged from 1-4 (median, 2), and the size of the cores ranged from 0.6-2 mm (median, 0.6 mm). Only 3 studies applied fluorescence in situ hybridization technology, while the remaining 34 studies used immunohistochemistry.CONCLUSION:
TMA can help to establish new prognostic markers and to define protein biomarkers that help in differential diagnosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endometrial Neoplasms
/
Tissue Array Analysis
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Anal Quant Cytol Histol
Journal subject:
HISTOLOGIA
Year:
2009
Type:
Article
Affiliation country:
Spain