A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide.

Sharabi, Amir; Dayan, Molly; Zinger, Heidy; Mozes, Edna

Sharabi, Amir; Dayan, Molly; Zinger, Heidy; Mozes, Edna.

Affiliation

Sharabi A; Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

J Clin Immunol ; 30(1): 34-44, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19756988

Subject(s)

Antibodies, Antinuclear/administration & dosage; Complementarity Determining Regions/administration & dosage; Kidney/metabolism; Lupus Erythematosus, Systemic/immunology; Peptide Fragments/administration & dosage; Animals; Antibodies, Antinuclear/chemistry; Antibodies, Monoclonal/immunology; Cells, Cultured; Complementarity Determining Regions/chemistry; Cytokines/biosynthesis; Cytokines/genetics; Disease Models, Animal; Forkhead Transcription Factors/biosynthesis; Forkhead Transcription Factors/genetics; Gene Expression Regulation/drug effects; Gene Expression Regulation/immunology; Humans; Immune Tolerance; Immunomodulation; Kidney/immunology; Lupus Erythematosus, Systemic/physiopathology; Lupus Erythematosus, Systemic/therapy; Mice; Peptide Fragments/chemistry; Swine/immunology; bcl-X Protein/biosynthesis; bcl-X Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Antibodies, Antinuclear / Complementarity Determining Regions / Kidney / Lupus Erythematosus, Systemic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Immunol Year: 2010 Type: Article Affiliation country: Israel

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