An experimental platform for systemic drug delivery to the retina.

Campbell, Matthew; Nguyen, Anh T H; Kiang, Anna-Sophia; Tam, Lawrence C S; Gobbo, Oliviero L; Kerskens, Christian; Ni Dhubhghaill, Sorcha; Humphries, Marian M; Farrar, G-Jane; Kenna, Paul F; Humphries, Peter

Campbell, Matthew; Nguyen, Anh T H; Kiang, Anna-Sophia; Tam, Lawrence C S; Gobbo, Oliviero L; Kerskens, Christian; Ni Dhubhghaill, Sorcha; Humphries, Marian M; Farrar, G-Jane; Kenna, Paul F; Humphries, Peter.

Affiliation

Campbell M; Ocular Genetics Unit, Department of Genetics, Trinity College Dublin, Dublin 2, Ireland. matthew.campbell@tcd.ie

Proc Natl Acad Sci U S A ; 106(42): 17817-22, 2009 Oct 20.

Article in En | MEDLINE | ID: mdl-19822744

Subject(s)

Blood-Retinal Barrier/drug effects; Blood-Retinal Barrier/metabolism; Drug Delivery Systems; Oligopeptides/administration & dosage; Animals; Calpain/antagonists & inhibitors; Claudin-5; Cysteine Proteinase Inhibitors/administration & dosage; Disease Models, Animal; Electroretinography; Guanosine Triphosphate/administration & dosage; Guanosine Triphosphate/metabolism; Humans; IMP Dehydrogenase/deficiency; IMP Dehydrogenase/genetics; Magnetic Resonance Imaging; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; RNA Interference; RNA, Small Interfering/genetics; Retina/drug effects; Retina/metabolism; Retinitis Pigmentosa/drug therapy; Retinitis Pigmentosa/genetics; Retinitis Pigmentosa/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Blood-Retinal Barrier / Drug Delivery Systems Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Type: Article Affiliation country: Ireland

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