AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

Sajan, M P; Bandyopadhyay, G; Miura, A; Standaert, M L; Nimal, S; Longnus, S L; Van Obberghen, E; Hainault, I; Foufelle, F; Kahn, R; Braun, U; Leitges, M; Farese, R V

Sajan, M P; Bandyopadhyay, G; Miura, A; Standaert, M L; Nimal, S; Longnus, S L; Van Obberghen, E; Hainault, I; Foufelle, F; Kahn, R; Braun, U; Leitges, M; Farese, R V.

Affiliation

Sajan MP; Research Service, James A. Haley Veterans Hospital and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA.

Am J Physiol Endocrinol Metab ; 298(2): E179-92, 2010 Feb.

Article in En | MEDLINE | ID: mdl-19887597

Subject(s)

Aminoimidazole Carboxamide/analogs & derivatives; Enzyme Activators/pharmacology; Glucose Transport Proteins, Facilitative/metabolism; Metformin/pharmacology; Muscle Fibers, Skeletal/drug effects; Protein Kinase C/metabolism; Ribonucleosides/pharmacology; AMP-Activated Protein Kinases/drug effects; AMP-Activated Protein Kinases/metabolism; Aminoimidazole Carboxamide/pharmacology; Animals; Blood Glucose/metabolism; Enzyme Activation/drug effects; Enzyme Activation/physiology; Extracellular Signal-Regulated MAP Kinases/drug effects; Extracellular Signal-Regulated MAP Kinases/metabolism; Glucose Transport Proteins, Facilitative/drug effects; Hypoglycemic Agents/pharmacology; In Vitro Techniques; Isoenzymes/genetics; Isoenzymes/metabolism; Male; Mice; Mice, Knockout; Muscle Fibers, Skeletal/metabolism; Physical Conditioning, Animal/physiology; Protein Kinase C/drug effects; Protein Kinase C/genetics; Rats; Second Messenger Systems/drug effects; Second Messenger Systems/physiology; Signal Transduction/drug effects; Signal Transduction/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleosides / Protein Kinase C / Muscle Fibers, Skeletal / Enzyme Activators / Glucose Transport Proteins, Facilitative / Aminoimidazole Carboxamide / Metformin Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2010 Type: Article Affiliation country: United States

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