Your browser doesn't support javascript.
loading
N3-arylmalonamides: a new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Saavedra, Oscar; Claridge, Stephen; Zhan, Lijie; Raeppel, Franck; Granger, Marie-Claude; Raeppel, Stéphane; Mannion, Michael; Gaudette, Frédéric; Zhou, Nancy; Isakovic, Ljubomir; Bernstein, Naomy; Déziel, Robert; Nguyen, Hannah; Beaulieu, Normand; Beaulieu, Carole; Dupont, Isabelle; Wang, James; Macleod, A Robert; Besterman, Jeffrey M; Vaisburg, Arkadii.
Affiliation
  • Saavedra O; Department of Medicinal Chemistry, 7220 Frederick-Banting, Montréal, QC, Canada H4S 2A1.
Bioorg Med Chem Lett ; 19(24): 6836-9, 2009 Dec 15.
Article in En | MEDLINE | ID: mdl-19896842
ABSTRACT
A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC(50) values in the low nanomolar range in vitro and were efficacious in human tumor xenograft models in mice in vivo.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Proto-Oncogene Proteins c-met / Vascular Endothelial Growth Factor Receptor-2 / Protein Kinase Inhibitors / Malonates / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Proto-Oncogene Proteins c-met / Vascular Endothelial Growth Factor Receptor-2 / Protein Kinase Inhibitors / Malonates / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article