Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.

Das, Arijit; Ko, Hyojin; Burianek, Lauren E; Barrett, Matthew O; Harden, T Kendall; Jacobson, Kenneth A

Das, Arijit; Ko, Hyojin; Burianek, Lauren E; Barrett, Matthew O; Harden, T Kendall; Jacobson, Kenneth A.

Affiliation

Das A; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

J Med Chem ; 53(1): 471-80, 2010 Jan 14.

Article in En | MEDLINE | ID: mdl-19902968

Subject(s)

Hexoses/chemistry; Purinergic P2 Receptor Agonists; Uridine Diphosphate Glucose/analogs & derivatives; Uridine Diphosphate Glucose/pharmacology; Alkylation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Conformation; Receptors, Purinergic P2/metabolism; Stereoisomerism; Structure-Activity Relationship; Uridine Diphosphate Glucose/chemistry

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uridine Diphosphate Glucose / Purinergic P2 Receptor Agonists / Hexoses Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google