Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.

Matthes, E; Bünger, H

Matthes, E; Bünger, H.

Affiliation

Matthes E; Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13092 Berlin, Germany. emat@mdc-berlin.de

Antimicrob Agents Chemother ; 54(1): 341-5, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19917760

Subject(s)

Antiviral Agents/pharmacology; Hepatitis B virus/drug effects; Zalcitabine/analogs & derivatives; Antiviral Agents/metabolism; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Cytidine Deaminase/pharmacology; Deoxycytidine/metabolism; Half-Life; Humans; Liver/metabolism; Phosphorylation; Zalcitabine/metabolism; Zalcitabine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Hepatitis B virus / Zalcitabine Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2010 Type: Article Affiliation country: Germany

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