Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning.
Proc Natl Acad Sci U S A
; 106(51): 21918-23, 2009 Dec 22.
Article
in En
| MEDLINE
| ID: mdl-19955404
ABSTRACT
Beta-arrestins, key regulators of receptor signaling, are highly expressed in the central nervous system, but their roles in brain physiology are largely unknown. Here we show that beta-arrestin-2 is critically involved in the formation of associative fear memory and amygdalar synaptic plasticity. In response to fear conditioning, beta-arrestin-2 translocates to amygdalar membrane where it interacts with PDE-4, a cAMP-degrading enzyme, to inhibit PKA activation. Arrb2(-/-) mice exhibit impaired conditioned fear memory and long-term potentiation at the lateral amygdalar synapses. Moreover, expression of the beta-arrestin-2 in the lateral amygdala of Arrb2(-/-) mice, but not its mutant form that is incapable of binding PDE-4, restores basal PKA activity and rescues conditioned fear memory. Taken together, our data demonstrate that the feedback regulation of amygdalar PKA activation by beta-arrestin-2 and PDE-4 complex is critical for the formation of conditioned fear memory.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyclic AMP-Dependent Protein Kinases
/
Conditioning, Operant
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Arrestins
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Cyclic Nucleotide Phosphodiesterases, Type 4
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Fear
/
Amygdala
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2009
Type:
Article
Affiliation country:
China