Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.

Bailly-Maitre, Béatrice; Belgardt, Bengt F; Jordan, Sabine D; Coornaert, Beatrice; von Freyend, Miriam John; Kleinridders, Andre; Mauer, Jan; Cuddy, Michael; Kress, Christina L; Willmes, Diana; Essig, Manuela; Hampel, Brigitte; Protzer, Ulrike; Reed, John C; Brüning, Jens C

Bailly-Maitre, Béatrice; Belgardt, Bengt F; Jordan, Sabine D; Coornaert, Beatrice; von Freyend, Miriam John; Kleinridders, Andre; Mauer, Jan; Cuddy, Michael; Kress, Christina L; Willmes, Diana; Essig, Manuela; Hampel, Brigitte; Protzer, Ulrike; Reed, John C; Brüning, Jens C.

Affiliation

Bailly-Maitre B; Department of Mouse Genetics and Metabolism, Institute for Genetics, Center of Molecular Medicine Cologne at the University of Cologne, Cologne, Germany.

J Biol Chem ; 285(9): 6198-207, 2010 Feb 26.

Article in En | MEDLINE | ID: mdl-19996103

Subject(s)

Endoribonucleases/antagonists & inhibitors; Glucose Intolerance/therapy; Insulin Resistance; Membrane Proteins/pharmacology; Obesity/complications; Protein Serine-Threonine Kinases/antagonists & inhibitors; Animals; Endoplasmic Reticulum/pathology; Genetic Therapy/methods; Gluconeogenesis/drug effects; Glucose/metabolism; Hyperglycemia/therapy; Liver/metabolism; Membrane Proteins/administration & dosage; Membrane Proteins/therapeutic use; Mice; Mice, Obese; Unfolded Protein Response

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Protein Serine-Threonine Kinases / Glucose Intolerance / Endoribonucleases / Membrane Proteins / Obesity Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2010 Type: Article Affiliation country: Germany

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