Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.

Boehringer, Markus; Fischer, Holger; Hennig, Michael; Hunziker, Daniel; Huwyler, Joerg; Kuhn, Bernd; Loeffler, Bernd M; Luebbers, Thomas; Mattei, Patrizio; Narquizian, Robert; Sebokova, Elena; Sprecher, Urs; Wessel, Hans Peter

Boehringer, Markus; Fischer, Holger; Hennig, Michael; Hunziker, Daniel; Huwyler, Joerg; Kuhn, Bernd; Loeffler, Bernd M; Luebbers, Thomas; Mattei, Patrizio; Narquizian, Robert; Sebokova, Elena; Sprecher, Urs; Wessel, Hans Peter.

Affiliation

Boehringer M; F Hoffmann-La Roche Ltd, Pharma Research, CH-4070 Basel, Switzerland.

Bioorg Med Chem Lett ; 20(3): 1106-8, 2010 Feb 01.

Article in En | MEDLINE | ID: mdl-20031408

Subject(s)

Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidase IV Inhibitors/chemistry; Quinolizines/chemistry; Animals; Crystallography, X-Ray; Dipeptidyl Peptidase 4/metabolism; Dipeptidyl-Peptidase IV Inhibitors/metabolism; Dipeptidyl-Peptidase IV Inhibitors/pharmacology; Humans; Protease Inhibitors/chemistry; Protease Inhibitors/metabolism; Protease Inhibitors/pharmacology; Quinolizines/metabolism; Quinolizines/pharmacology; Rats; Rats, Zucker

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolizines / Dipeptidyl-Peptidase IV Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: Switzerland

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