Randomized clinical trial of long-acting oxytetracycline, foot trimming, and flunixine meglumine on time to recovery in sheep with footrot.
J Vet Intern Med
; 24(2): 420-5, 2010.
Article
in En
| MEDLINE
| ID: mdl-20051002
ABSTRACT
BACKGROUND:
Internationally, foot trimming is used by most farmers, and parenteral antibacterials by some, to treat sheep with footrot. Nonsteroidal anti-inflammatory drugs (NSAID) are sometimes used. No clinical trials have compared these treatments.OBJECTIVES:
To investigate the above treatments on time to recovery from lameness and foot lesions in sheep with footrot. ANIMALS Fifty-three sheep with footrot on a commercial farm in England.METHODS:
In a randomized factorial design, the sheep were allocated to 6 treatment groups. The treatments were oxytetracycline spray to all sheep (positive control) and one or more of parenteral administration of long-acting oxytetracycline, flunixine meglumine, and foot trimming on day 1 or 6 of diagnosis. Follow-up was for 15 days. Time to recovery from lameness and lesions was investigated with discrete-time survival models.RESULTS:
There was significant association (P < .05) between recovery from lameness and lesions. Sheep receiving antibacterials parenterally recovered faster from lameness (odds ratio [OR] 4.92 [1.20-20.10]) and lesions (OR 5.11 [1.16-22.4]) than positive controls, whereas sheep foot trimmed on day 1 (lameness-OR 0.05 [0.005-0.51]; lesions-OR 0.06 [0.008-0.45]) or day 6 of diagnosis (lameness OR 0.07 [0.01-0.72]; lesions OR 0.07 [0.01-04).56]) recovered more slowly than positive controls. NSAID had no significant effect on recovery. CONCLUSIONS AND CLINICAL IMPORTANCE If foot trimming on day 1 or 6 of diagnosis was stopped and parenteral antibacterials were used, then over 1 million sheep/annum lame with footrot in the United Kingdom would recover more rapidly with benefits to productivity. Globally, this figure would be much higher.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxytetracycline
/
Sheep Diseases
/
Clonixin
/
Foot Diseases
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Vet Intern Med
Journal subject:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Year:
2010
Type:
Article
Affiliation country:
United kingdom