Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.

Isenman, David E; Leung, Elisa; Mackay, Julia D; Bagby, Stefan; van den Elsen, Jean M H

Isenman, David E; Leung, Elisa; Mackay, Julia D; Bagby, Stefan; van den Elsen, Jean M H.

Affiliation

Isenman DE; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. d.isenman@utoronto.ca

J Immunol ; 184(4): 1946-55, 2010 Feb 15.

Article in En | MEDLINE | ID: mdl-20083651

Subject(s)

Bacterial Proteins/chemistry; Carrier Proteins/chemistry; Complement C3d/chemistry; Immune Evasion; Receptors, Complement 3d/chemistry; Staphylococcus aureus/immunology; Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Line; Complement C3b/antagonists & inhibitors; Complement C3b/genetics; Complement C3b/metabolism; Complement C3d/genetics; Complement C3d/metabolism; Crystallization; Crystallography, X-Ray; DNA Mutational Analysis; Humans; Immune Evasion/genetics; Mice; Mutagenesis, Site-Directed; Peptide Fragments/antagonists & inhibitors; Peptide Fragments/genetics; Peptide Fragments/metabolism; Receptors, Complement 3d/antagonists & inhibitors; Receptors, Complement 3d/genetics; Staphylococcus aureus/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Bacterial Proteins / Carrier Proteins / Complement C3d / Receptors, Complement 3d / Immune Evasion Limits: Animals / Humans Language: En Journal: J Immunol Year: 2010 Type: Article Affiliation country: Canada

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