A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.

Zhou, Qing; Gustafson, Daniel; Nallapareddy, Sujatha; Diab, Sami; Leong, Stephen; Lewis, Karl; Gore, Lia; Messersmith, Wells A; Treston, Anthony M; Eckhardt, S Gail; Sidor, Carolyn; Camidge, D Ross

Zhou, Qing; Gustafson, Daniel; Nallapareddy, Sujatha; Diab, Sami; Leong, Stephen; Lewis, Karl; Gore, Lia; Messersmith, Wells A; Treston, Anthony M; Eckhardt, S Gail; Sidor, Carolyn; Camidge, D Ross.

Affiliation

Zhou Q; Developmental Therapeutics Program, Division of Medical Oncology, University of Colorado, Aurora, CO 80045, USA.

Invest New Drugs ; 29(2): 340-6, 2011 Apr.

Article in En | MEDLINE | ID: mdl-20084425

Subject(s)

Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/therapeutic use; Estradiol/analogs & derivatives; Estrenes/pharmacokinetics; Estrenes/therapeutic use; Neoplasms/drug therapy; 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/adverse effects; Demography; Dogs; Dose-Response Relationship, Drug; Estradiol/administration & dosage; Estradiol/adverse effects; Estradiol/pharmacokinetics; Estradiol/therapeutic use; Estrenes/administration & dosage; Estrenes/adverse effects; Female; Humans; Male; Middle Aged; Neoplasms/blood; Rats; Species Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Estradiol / Estrenes / Neoplasms / Antineoplastic Agents Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2011 Type: Article Affiliation country: United States

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