Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells.

Okazaki, Hirokazu; Shioi, Atsushi; Hirowatari, Kaname; Koyama, Hidenori; Fukumoto, Shinya; Ishimura, Eiji; Nishizawa, Yoshiki

Okazaki, Hirokazu; Shioi, Atsushi; Hirowatari, Kaname; Koyama, Hidenori; Fukumoto, Shinya; Ishimura, Eiji; Nishizawa, Yoshiki.

Affiliation

Okazaki H; Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. m1152952@med.osaka-cu.ac.jp

Osaka City Med J ; 55(2): 71-80, 2009 Dec.

Article in En | MEDLINE | ID: mdl-20088406

Subject(s)

Calcinosis/chemically induced; Calcinosis/physiopathology; Inflammation Mediators/adverse effects; Muscle, Smooth, Vascular/physiopathology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Alkaline Phosphatase/metabolism; Androstadienes/pharmacology; Calcinosis/metabolism; Calcitriol/adverse effects; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Interferon-gamma/adverse effects; Muscle, Smooth, Vascular/pathology; Oncostatin M/adverse effects; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; RNA, Small Interfering/pharmacology; Signal Transduction; Tumor Necrosis Factor-alpha/adverse effects; Wortmannin

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Collection: 01-internacional Database: MEDLINE Main subject: Calcinosis / Inflammation Mediators / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Muscle, Smooth, Vascular Limits: Humans Language: En Journal: Osaka City Med J Year: 2009 Type: Article Affiliation country: Japan

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