Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

Polgar, Orsolya; Ierano, Caterina; Tamaki, Akina; Stanley, Bradford; Ward, Yvona; Xia, Di; Tarasova, Nadya; Robey, Robert W; Bates, Susan E

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

Polgar, Orsolya; Ierano, Caterina; Tamaki, Akina; Stanley, Bradford; Ward, Yvona; Xia, Di; Tarasova, Nadya; Robey, Robert W; Bates, Susan E.

Affiliation

Polgar O; Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, Maryland 20892, USA.

Biochemistry ; 49(10): 2235-45, 2010 Mar 16.

Article in En | MEDLINE | ID: mdl-20088606

Subject(s)

ATP-Binding Cassette Transporters/chemistry; ATP-Binding Cassette Transporters/genetics; Cell Membrane/metabolism; Mutation; Neoplasm Proteins/chemistry; Neoplasm Proteins/genetics; Protein Multimerization; Protein Structure, Quaternary; Threonine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/metabolism; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cross-Linking Reagents/pharmacology; DNA Mutational Analysis; Gene Expression Regulation; Glycoside Hydrolases/metabolism; Humans; Leupeptins/pharmacology; Macrolides/pharmacology; Mitoxantrone/pharmacology; Molecular Sequence Data; Neoplasm Proteins/metabolism; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/metabolism; Protein Transport/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Threonine / Cell Membrane / ATP-Binding Cassette Transporters / Protein Structure, Quaternary / Protein Multimerization / Mutation / Neoplasm Proteins Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2010 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google