Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2.

Britschgi, Adrian; Simon, Hans-Uwe; Tobler, Andreas; Fey, Martin F; Tschan, Mario P

Britschgi, Adrian; Simon, Hans-Uwe; Tobler, Andreas; Fey, Martin F; Tschan, Mario P.

Affiliation

Britschgi A; Department of Clinical Research, Experimental Oncology/Haematology, Bern University Hospital, Switzerland.

Br J Haematol ; 149(1): 55-64, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20096012

Subject(s)

Antineoplastic Agents/pharmacology; Catechin/analogs & derivatives; Leukemia, Myeloid, Acute/pathology; Neutrophils/drug effects; Tretinoin/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Apoptosis Regulatory Proteins/physiology; Calcium-Calmodulin-Dependent Protein Kinases/physiology; Catechin/pharmacology; Cell Death/drug effects; Cell Differentiation/drug effects; Death-Associated Protein Kinases; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical/methods; Gene Knockdown Techniques; Humans; Reverse Transcriptase Polymerase Chain Reaction/methods; Tumor Cells, Cultured; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Leukemia, Myeloid, Acute / Catechin / Neutrophils / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2010 Type: Article Affiliation country: Switzerland

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