Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh, Dilip K; Yoo, Lena S; Chinn, Moshe; Hong, Kunlun; Kilbey, S Michael; Barrett, Matthew O; Fricks, Ingrid P; Harden, T Kendall; Gao, Zhan-Guo; Jacobson, Kenneth A

Tosh, Dilip K; Yoo, Lena S; Chinn, Moshe; Hong, Kunlun; Kilbey, S Michael; Barrett, Matthew O; Fricks, Ingrid P; Harden, T Kendall; Gao, Zhan-Guo; Jacobson, Kenneth A.

Affiliation

Tosh DK; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Bioconjug Chem ; 21(2): 372-84, 2010 Feb 17.

Article in En | MEDLINE | ID: mdl-20121074

Subject(s)

Adenosine A3 Receptor Agonists; Dendrimers/chemistry; Receptors, Purinergic P2/metabolism; Uridine Diphosphate Glucose/chemistry; Uridine Diphosphate Glucose/pharmacology; Adenosine/chemistry; Alkynes/chemistry; Amides/chemistry; Animals; CHO Cells; Catalysis; Cell Line, Tumor; Copper/chemistry; Cricetinae; Cricetulus; Humans; Ligands; Neuroimmunomodulation/drug effects; Triazoles/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uridine Diphosphate Glucose / Receptors, Purinergic P2 / Dendrimers / Adenosine A3 Receptor Agonists Limits: Animals / Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2010 Type: Article Affiliation country: United States

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