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Potential of Macrostomum lignano to recover from gamma-ray irradiation.
De Mulder, Katrien; Kuales, Georg; Pfister, Daniela; Egger, Bernhard; Seppi, Thomas; Eichberger, Paul; Borgonie, Gaetan; Ladurner, Peter.
Affiliation
  • De Mulder K; Institute of Zoology and Center for Molecular Biosciences, University of Innsbruck, Austria.
Cell Tissue Res ; 339(3): 527-42, 2010 Mar.
Article in En | MEDLINE | ID: mdl-20127258
ABSTRACT
Stem cells are the only proliferating cells in flatworms and can be eliminated by irradiation with no damage to differentiated cells. We investigated the effect of fractionated irradiation schemes on Macrostomum lignano, namely, on survival, gene expression, morphology and regeneration. Proliferating cells were almost undetectable during the first week post-treatment. Cell proliferation and gene expression were restored within 1 month in a dose-dependent manner following exposure to up to 150 Gy irradiation. During recovery, stem cells did not cross the midline but were restricted within lateral compartments. An accumulated dose of 210 Gy resulted in a lethal phenotype. Our findings demonstrate that M. lignano represents a suitable model system for elucidating the effect of irradiation on the stem cell system in flatworms and for improving our understanding of the recovery potential of severely damaged stem-cell systems.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regeneration / Turbellaria / Gamma Rays Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Tissue Res Year: 2010 Type: Article Affiliation country: Austria

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regeneration / Turbellaria / Gamma Rays Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Tissue Res Year: 2010 Type: Article Affiliation country: Austria