Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Proc Natl Acad Sci U S A
; 107(10): 4640-5, 2010 Mar 09.
Article
in En
| MEDLINE
| ID: mdl-20176933
ABSTRACT
Dietary fat accumulates in lipid droplets or endolysosomal compartments that undergo selective expansion under normal or pathophysiological conditions. We find that genetic defects in a peroxisomal beta-oxidation pathway cause size expansion in lipid droplets that are distinct from the lysosome-related organelles in Caenorhabditis elegans. Expansion of lipid droplets is accompanied by an increase in triglycerides (TAG) that are resistant to fasting- or TAG lipase-triggered lipolysis. Nevertheless, in mutant animals, a diet poor in vaccenic acid reduced the TAG level and lipid droplet size. Our results implicate peroxisomal dysfunction in pathologic lipid droplet expansion in animals and illustrate how dietary factors modulate the phenotype of such genetic defects.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caenorhabditis elegans
/
Cytoplasmic Granules
/
Lipid Metabolism
/
Lipids
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2010
Type:
Article
Affiliation country:
United States