Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

Krebiehl, Guido; Ruckerbauer, Sabine; Burbulla, Lena F; Kieper, Nicole; Maurer, Brigitte; Waak, Jens; Wolburg, Hartwig; Gizatullina, Zemfira; Gellerich, Frank N; Woitalla, Dirk; Riess, Olaf; Kahle, Philipp J; Proikas-Cezanne, Tassula; Krüger, Rejko

Krebiehl, Guido; Ruckerbauer, Sabine; Burbulla, Lena F; Kieper, Nicole; Maurer, Brigitte; Waak, Jens; Wolburg, Hartwig; Gizatullina, Zemfira; Gellerich, Frank N; Woitalla, Dirk; Riess, Olaf; Kahle, Philipp J; Proikas-Cezanne, Tassula; Krüger, Rejko.

Affiliation

Krebiehl G; Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

PLoS One ; 5(2): e9367, 2010 Feb 23.

Article in En | MEDLINE | ID: mdl-20186336

Subject(s)

Autophagy; Intracellular Signaling Peptides and Proteins/genetics; Mitochondria/metabolism; Oncogene Proteins/genetics; Animals; Blotting, Western; Fibroblasts/cytology; Fibroblasts/metabolism; Fibroblasts/ultrastructure; Humans; Intracellular Signaling Peptides and Proteins/metabolism; Lysosomes/metabolism; Lysosomes/ultrastructure; Mice; Mice, Knockout; Microscopy, Electron; Mitogen-Activated Protein Kinase 1/metabolism; Mutation; Oncogene Proteins/metabolism; Oxidative Phosphorylation; Parkinson Disease/genetics; Parkinson Disease/pathology; Peroxiredoxins; Phosphorylation; Protein Deglycase DJ-1; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Oncogene Proteins / Intracellular Signaling Peptides and Proteins / Mitochondria Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2010 Type: Article Affiliation country: Germany

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