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Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.
Reddy, M V Ramana; Pallela, Venkat R; Cosenza, Stephen C; Mallireddigari, Muralidhar R; Patti, Revathi; Bonagura, Marie; Truongcao, May; Akula, Balaiah; Jatiani, Shashidhar S; Reddy, E Premkumar.
Affiliation
  • Reddy MVR; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Pallela VR; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Cosenza SC; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Mallireddigari MR; Onconova Therapeutics Inc., 375 Pheasant Run, Newtown, PA 18940, United States.
  • Patti R; Onconova Therapeutics Inc., 375 Pheasant Run, Newtown, PA 18940, United States.
  • Bonagura M; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Truongcao M; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Akula B; Onconova Therapeutics Inc., 375 Pheasant Run, Newtown, PA 18940, United States.
  • Jatiani SS; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
  • Reddy EP; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, United States.
Bioorg Med Chem ; 18(6): 2317-2326, 2010 Mar 15.
Article in En | MEDLINE | ID: mdl-20188579
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Drug Design / Fusion Proteins, bcr-abl / Chalcones / Protein Kinase Inhibitors Type of study: Evaluation_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Drug Design / Fusion Proteins, bcr-abl / Chalcones / Protein Kinase Inhibitors Type of study: Evaluation_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States